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Effects of Lidocaine on Ropivacaine Pharmacodynamics and Pharmacokinetic for Lumbar Plexus Combined Sciatic Nerve Blockade: A Double-Blind Randomized Study

Effects of Lidocaine on Ropivacaine Pharmacodynamics and Pharmacokinetic for Lumbar Plexus Combined Sciatic Nerve Blockade: A Double-Blind Randomized Study

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR-ORC-12002099
Enrollment
Unknown
Registered
2012-04-09
Start date
2009-09-10
Completion date
Unknown
Last updated
2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee joint injury

Interventions

Group r:Sciatic nerve blockade was performed using a solution of 10 mL N.S. and then 10 mL ropivacaine 0.75%
Group lr:Sciatic nerve blockade was performed using a solution of 10 mL lidocaine 2% and then a solution of 10 mL ropivacaine 0.75%
Group R:Sciatic nerve blockade was performed using a solution of 10 mL N.S. and then 10 mL ropivacaine 0.75%
Group LR:Sciatic nerve blockade was performed using a solution of 10 mL lidocaine 2% and then a solution of 10 mL ropivacaine 0.75%

Sponsors

The First Affiliated Hospital of Wenzhou Medical College
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 50 Years

Inclusion criteria

Inclusion criteria: ASA physical status I~II, age 18~50yr, weight 50~75kg, scheduled to undergo knee joint surgery with combined lumbar plexus-sciatic nerve block.

Exclusion criteria

Exclusion criteria: patient refusal, anticoagulant treatment, allergy to local anesthetics, neurologic or neuromuscular disease, severe liver or renal insufficiency, women of childbearing age or patients unlikely to be fully cooperative during the study.

Design outcomes

Primary

MeasureTime frame
concentration of ropivacaine;concentration of lidocaine;time to sensory recover;

Secondary

MeasureTime frame
Sensory onset time;

Countries

China

Contacts

Public ContactXuzhong Xu
xuzhong@263.net+86 13706657799

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026