Hyperprolactinemia
Conditions
Interventions
Experimental group:cured by Kuntai Capsule
Sponsors
Shanghai Mental Health Center
Eligibility
Sex/Gender
Female
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: Patients who met the following inclusion criteria were eligible for the study: 1. Women aged 18 to 55 years; 2. a primary diagnosis of schizophrenia based on the Diagnostic and Statistical Manual of Mental Disorders,4th Revision, now in stable condition, and score of Positive and Negative Syndrome Scale(PANSS) less than 60; 3. patients of outpatient and inpatient department are taking olanzapine or risperidone antipsychotic medications, if take cold medications at the same time, take in this study only after drug withdrawal; 4. had one of the following situations after taking the medications, and specific criteria see below, including (1) breast pain, defined as breast swell, itch or nipple bulge pain; (2)menstrual, including pre-menstrual, delayed menorrhea, irregularly menstrual, menorrhagia and hypomenorrhea, menostaxis. Pre-menstrual defined as menstrual cycle was advanced for 7 days, and last 3 menstrual cycles. Delayed menorrhea defined as menstrual cycle was prolonged for 7 days, and last 3 menstrual cycles. Irregularly menstrual defined as menstrual cycle was advanced or prolonged for 7 days, and for 3 menstrual cycles. Menorrhagia defined as every time the total menstrual quantity more than 80 mL and hypomenorrhea defined as every time the total menstrual quantity less than 20 mL or 2 days. Menostaxis defined as normal cycle and menstrual period more than 7 days; (3) amenorrhea defined as the absence of menstruation for 3 menstrual cycles; (4)galactorrhea defined as starts to lactate during non-lactation. 5. Level of serum prolactin higher than 540 mIU/L; 6. All participants and their guardians gave voluntary, written, informed consent before entering the trial.
Exclusion criteria
Exclusion criteria: 1. Pregnant and lactating; 2. taking the oral contraceptives for a long time; 3. have obvious physical and nervous system disease in such as heart, liver, kidney ; 4. a history of alcoholism and drug dependence; 5. a primary organic adenomas in the hypothalamus, pituitary gland 6. polycystic ovarian syndrome; 7. primary decreased ovarian reserve; 8. Endometriosis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| level of prolactin;Clinical symptoms (e.g., breast tenderness, menoxenia, amenorrhea, lactation, etc.); | — |
Secondary
| Measure | Time frame |
|---|---|
| PANSS;PSQI; | — |
Countries
China
Contacts
Public ContactYuan Chengmei
Shanghai Mental Health Center
Outcome results
None listed