diseases of urinary system
Conditions
Interventions
Group A:Single RLQ_PK
Group B:Multiple RLQ_PK
Group C:DDI_Ciprofloxacin
Group D:DDI_RLQ_multi +CIP
Group E:DDI_RLQ_single+CIP
Sponsors
Second affiliated hospital of Tianjin University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 35 Years
Inclusion criteria
Inclusion criteria: (1) Healthy subjects aged 18~35 years old, and the age difference should less than 10 years in the same batch; (2) Body weight should more than 50 kg, and BMI in range of 19~24kg/m2 [BMI=weight (kg)/height 2(m2)]; (3) General physical examination, laboratory examination, chest electrocardiogram and other physical and chemical inspection should be normal; (4) No history of major diseases, no smoking history of alcoholism, urine pregnancy test should be negative for childbearing age women; (5) Subject is able to communicate with investigator well and comply with requires of study and sign the informed consent.
Exclusion criteria
Exclusion criteria: (1) Participated in other clinical subjects within 3 months; (2) Blood donation in the last 1 month or intend to donate blood in the following 1 month; (3) Used any medicine in the last 2 weeks; (4) Any medical history of cardiovascular, hepatic, kidney, gastrointestinal tract, and nervous system, metabolic disturbance, etc; (5) The general examination and blood pressure, heart rate and respiratory conditions are not qualified; (6) Physical examination found that there are any significant clinical symptoms; (7) Laboratory test (hematology, urine analysis, blood biochemistry, ECG examination and the four markers) results judged as Heart, liver and kidney dysfunction; (8) Women in gestation period and lactation period, and menstrual period; (9) Allergic constitution: the persons allergic to two or more medicines, food and pollen or ingredients of investigator produc; (10) Drug abusers, tobacco and alcohol addiction; (11) Unsuitable to participate in the trial considered by the researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| protocatechuic acid in plasma;gallic acid in plasma;Ciprofloxacin in plasma;protocatechuic acid in urine;gallic acid in urine; | — |
Countries
China
Contacts
Public ContactHuang Yuhong
Second affiliated hospital of Tianjin University of Traditional Chinese Medicine
Outcome results
None listed