NSCLC
Conditions
Interventions
A:Apatinib + Docetaxel + Platinum
B: Docetaxel + Platinum
Sponsors
2nd People's Hospital of Fuyang City
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18~75 years old, man or woman; 2. The pathological/cytology diagnosis of Primary advanced Non-small cell lung cancer patients,with measurable focus (the longest tumor diameter >=10mm, the smallest nodule >=15mm and the slice thickness =90 g/L; ANC>=1.5*10^9/L; PLT>=80*10^9/L; (2) TBIL 45 ml/min (Cockcroft-Gault formula); 8. women of childbearing age must have taken reliable contraceptive measures or 7 days before the group performed a pregnancy test (serum or urine), and the result is negative, and willing to experiment and during the last eight weeks after administration of the test drugs using appropriate methods contraception. For men shall be agreed to during the trial and after the last administration of the test drugs eight weeks using appropriate methods of contraception or sterilization surgery; 9. The subjects voluntarily joined the study, and informed consent, good compliance, with the follow-up.
Exclusion criteria
Exclusion criteria: 1. pregnant or lactating; 2. After suffering from high blood pressure and antihypertensive medications can not fall within the normal range (systolic blood pressure> 140 mmHg, diastolic blood pressure> 90 mmHg) above the level of suffering I myocardial ischemia,myocardial infarction, arrhythmia or Class II cardiac sufficiency; 3. coagulation abnormalities (INR> 1.5 or APTT>1.5ULN + 4 seconds, or APTT>1.5 ULN), having bleeding tendency,or treated with thrombolysis and anticoagulation; 4. Patients with clear gastrointestinal bleeding concerns(including the following situations: local active ulcerative lesions, and defecate occult blood (++)); A period of 6 months prior to the start of the study gastrointestinal bleeding event has occurred; 5. Unresolved = CTCAE 2 toxicity caused by the original treatment; 6. Have a variety of factors that affect the taking and absorption of oral drugs ; such as can not swallow, chronic diarrhea and intestinal obstruction, significantly affect the taking and absorption of drugs, etc. 7. Investigator judgment that may affect the conduct of clinical studies and case studies determined.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PFS; | — |
Countries
China
Contacts
Public ContactFengde Zhao
2nd People's Hospital of Fuyang City
Outcome results
None listed