Cerebral vascular structure, dysfunction and related diseases
Conditions
Interventions
ctonrol group:Routine treatments for acute ischemic patients such as anti-platelet aggregation, anti-hypertension, lipid lowering, glycemic control depending on individual conditions.
NBP group:dl-3-n-butylphthalide, and also give routine treatments for acute ischemic stroke patients the same as control group.
Sponsors
The First Affiliated Hospital of Xinxiang Medical University
Eligibility
Sex/Gender
All
Age
29 Years to 60 Years
Inclusion criteria
Inclusion criteria: All the cases were diagnosed in line with the Fourth National Conference of cerebrovascular disease diagnostic criteria adopted by the skull CT or MRI confirmed. TOAST etiology of atherosclerosis and small artery occlusion were patients. There was no significant poststroke dysfunction in the patients. The National Institutes of Health Stroke Scale (NIHSS) score was 2 to 12 (median, 6). Patients with severe visual acuity, hearing impairment, to complete the scale assessment, the better the compliance of the researchers. No severe systemic complications (such as various acute and chronic inflammation, connective tissue disease, cancer, atrial fibrillation, heart failure, respiratory failure, liver and kidney dysfunction, blood diseases, malignancies.
Exclusion criteria
Exclusion criteria: 1. before the onset of cognitive dysfunction and mental disorders, pregnancy, breast-feeding women; 2. Before the onset of use of folic acid, vitamin B6 and vitamin B12 and other drugs; 3. Patients who are in serious condition or unable to complete the medication and cognitive function scale due to disability; 4. Emergency thrombolysis or interventional therapy were excluded; 5. Subjects withdrawn from the standard: 5.1 It is necessary for the subject to discontinue the test for the study of drug allergy or the investigator's medical consideration. 5.2 The subject or his family request withdrawal test.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| high-sensitivity C-reactive protein(hs-CRP);hepatocyte growth factor(HGF);Oxidized low-density lipoprotein(ox-LDL);Montreal cognitive assessment (MoCA);Minimum Mental State Examination;regional cerebral blood flows (rCBF);regional cerebral blood volume (rCBV);mean transit time (MTT);time to peak (TTP); | — |
Countries
China
Contacts
Public ContactZhang Ping
The First Affiliated Hospital of Xinxiang Medical University
Outcome results
None listed