Lupus Nephritis
Conditions
Interventions
Treat group:umbilical cord mesenchymal stem cell transplantation
Sponsors
Department of Nephrology; The First Affiliated Hospital of the Third Military Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: (1) Aged 18-60 years old male and female; (2) Meet the Emendatory SLE diagnostic criteria of The American rheumatism association (1982); (3) Patient with pathologically confirmed Lupus nephritis III-IV-SIV-GV or III+VIV+ V type; (4) The Clinical diagnosis of refractory with lupus nephritis is confirmed (Proteinuria > 1 g/d After 24 weeks of treatment or down less than 25%, compared with before treatment and exclusion of reversible factors; The SLEDAI score > 8).
Exclusion criteria
Exclusion criteria: (1) With other autoimmune diseases, connective tissue diseases, amyloidosis; (2) The pulmonary artery pressure 50 mmHg or higher; (3) Any more complicated medical problems may interfere with the action or result in increased risk, such as malignant tumor, diabetes, blood disease, heart disease, liver disease, AIDS, viral hepatitis and other acquired and congenital immunodeficiency disease, or has a history of organ transplantation, etc; (4) Allergic to any culture cell component; (5) Clinically active infection; (6) Couldn't understand the potential risks and benefits of research, unable to follow-up assessment as required; (7) No capacity for civil conduct; (8) The history of drug or alcohol abuse; (9) Pregnancy or lactation; (10) Researchers think not appropriate for clinical subjects.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 24-hours proteinuria;Serum albumin; | — |
Secondary
| Measure | Time frame |
|---|---|
| recurrence rate;remission rate;mortality;complement C3;dsDNA;Sm antibody;Serum creatine;eGFR-EPI;SLEDAI ??; | — |
Countries
China
Contacts
Public ContactZhao Hongwen
Department of Nephrology; the First Affiliated Hospital of the Third Military Medical University
Outcome results
None listed