Acute cerebral infarction, transient ischemic attack
Conditions
Interventions
The unfractionated heparin Group:Daily given unfractionated 100mg by intravenous, continuous 5-7 days.Then the operator give patients with aspirin 200mg/day for 7 days. 15-90 days give aspirin 100mg/d
Dual antiplatelet drugs therapy group (aspirin plus clopidogrel):The operator give patient with clopidogrel 300 mg +aspirin 100mg on the first day
2-14 days give Dual Antiplatelet Therapy: clopidogrel 75 mg/d +aspirin 100 mg/d .15-90 days give aspirin 100mg/day.
Single antiplatelet drug therapy group (aspirin):The operator give patient with aspirin 300mg on the first day
2-14 days give aspirin 200 mg/d .15-90 days give aspirin 100mg/day.
Sponsors
The Department of Neurology, The Second Affiliated Clinical Hospital Of Harbin Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Aged 18 to 85 years old; The onset time: within 7 days of admission; Diagnosis of cerebral infarction TIA (NIHSS score <=16 points); Removal of intracranial hemorrhage with head CT; Signed informed consent; Choose better compliance patients, in order to complete test and observation.
Exclusion criteria
Exclusion criteria: Previous intracranial hemorrhage, including suspected subarachnoid hemorrhage; The history of traumatic brain injury in the last 3 months; There were gastrointestinal or urinary tract bleeding in the past 3 weeks;Over the past 2 weeks to carry out a large surgery; in the past 1 weeks, there is a puncture in the artery which is not easy to stop bleeding; Physical examination revealed evidence of active bleeding or trauma (such as fractures); Severe heart, liver, kidney and other important organ function damage and blood disease; Anticoagulation, thrombolysis and fibrinolysis were carried out within 24 hours; There was a history of gout,asthma, peptic ulcer and heparin or anti platelet aggregation drug allergy or any other history of allergies; Blood pressure: systolic blood pressure >180mmHg, or diastolic blood pressure >100mmHg; Abnormal coagulation function (such as APTT abnormalities and platelet <100*10^9/L, etc.); Pregnancy and lactation; Cardioembolism.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The NIHSS score;The SSS score;The general condition and mental state assessment;The Ranking Score;The ABCD2 Score;The attack times of TIA;Episode duration of TIA;Whether the progression of cerebral infarction; | — |
Secondary
| Measure | Time frame |
|---|---|
| The treatment time of stable condition and improved;The finish event evaluation;Bleeding events evaluation;The finish event evaluation;Bleeding events evaluation; | — |
Countries
China
Contacts
Public ContactFu Jin
The Department of Neurology, The Second Affiliated Clinical Hospital of Harbin Medical University
Outcome results
None listed