acute coronary syndrome (ACS)
Conditions
Interventions
ticagrelor group:ticagrelor
Sponsors
Fuwai Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: (1) Patients presenting to the Emergency and Intensive Care Center of Fuwai Hospital with definite diagnosis of ACS including ST-segment elevation myocardial infarction (STEMI), non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA); (2) Newly happened, aggravated, and typical ischemic chest pain within 48 hours including duration of symptoms last more than five minutes or need of taking nitroglycerin sublindual to alleviate the pain; (3) Having not taken clopidogrel or ticagrelor for antiplatelet therapy before admission or withdrawing these drugs for at least one month; (4) Taking small dosage aspirin 75-100 mg/day for one month before admission; (5) Agree to sign the informed consent.
Exclusion criteria
Exclusion criteria: (1) Contraindication to clopidogrel or ticagrelor; (2) With active pathological bleeding (such as pepticulcer or intracranial hemorrhage); (3) With a history of intracranial hemorrhage; (4) Having received thrombolysis treatment for this cardiac attack; (5) With severe liver disease or serum total bilirubin more than 1.5 times the upper normal limit; (6) With definite kidney disease or the endogenous creatinine clearance rate (Ccr) less than 30 ml/min; (7) A platelet count less than 100000 mm3, a hematocrit less than 25% or more than 50%; (8) Using of potent CYP3A4 inhibitors, such as: ketoconazole, clindamycin, nefazodone, ritonavir and atazanavir); (9) To be aged younger than 18 years, or not signed informed consent; (10) Other conditions the clinical doctors think not suitable for use of the drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| platelet aggregation; | — |
Countries
China
Contacts
Public ContactYan Liang
Outcome results
None listed