Acute Ischemic Stroke
Conditions
Interventions
UK:1.2 million U or 1.5 million U dissolved in 100ml sodium chloride injection, 30 minutes intravenously finished
rtpa:According to 0.6mg / kg or 0.9mg / kg alteplase, of which 10% intravenous injection, the remaining 60 minutes intravenous infusion
Sponsors
The General Hospital of Shenyang Military Region
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1) aged =18 years; 2) meet the diagnostic criteria for the diagnosis and treatment of acute ischemic stroke in China 2014; 3) the first onset or previous history of cerebral infarction without significant sequelae (mRS = 1); 4) within 6 hours of onset; 5) Patients or legal guardians are able to understand and sign informed consent.
Exclusion criteria
Exclusion criteria: Absolute exclusion criteria: 1. Significant history of head trauma or stroke in the last 3 months; 2. Suspected subarachnoid hemorrhage; 3. History of previous intracranial hemorrhage; 4. Intracranial neoplasms, arteriovenous malformations or aneurysms; 5. intracranial or spinal surgery in the near future; 6. arterial puncture in the last 7 days; 7. elevated blood pressure: systolic blood pressure =180 mm Hg, or diastolic blood pressure = 100 mm Hg; 8. activity; 9. acute bleeding tendency, including platelet count less than 100×10^9/L or other conditions; 10. received heparin treatment within 48 h (APTT exceeded the upper limit of normal range); 11. oral anticoagulant, INR> 1.7 Or PT> 15S; 12. are currently using thrombin inhibitors or Xa factor inhibitors, various sensitive laboratory tests (eg APTT, INR, platelet count, ECT; TT or appropriate Xa factor activity assay); 13. Blood glucose 1/3 cerebral hemisphere); 15. Researchers are not considered eligible for other clinical studies; 16. within 3 months or are participating in other clinical trials; 17. combined with severe systemic systemic disease is expected to survive less than three months: 1) severe stroke (NIHSS> 25 points); 2) pregnancy; 3) residual neurological deficits after epileptic seizures; 4) major surgery or severe trauma in the last 14 days; 5) Urethral bleeding; 6) myocardial infarction in the last 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| mRS; | — |
Secondary
| Measure | Time frame |
|---|---|
| NIHSS;Recurrent Stroke; | — |
Countries
China
Contacts
Public ContactHuisheng Chen
The General Hospital of Shenyang Military Region
Outcome results
None listed