post Stroke Depression
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1) Aged 18-80 years old, male or female; 2) ischemic stroke confirmed with CT or MRI (onset within 7 days after admission); 3) Within 30 days after the onset of stroke, and mRS = 3 points; 4) signed informed consent.
Exclusion criteria
Exclusion criteria: 1) mRS = 4 points; 2) With severe hypertension not well controlled (after drug treatment, systolic blood pressure > 180mmHg or diastolic blood pressure > 110mmHg); 3) Patients with malignant tumors; 4) Are clearly associated with any of the following cardiogenic embolism-related diseases: rheumatic mitral or aortic stenosis, artificial heart valve, atrial fibrillation, atrial flutter, sick sinus syndrome, left atrial myxoma, Necrosis of the left ventricle, left ventricular sulcus or valve neoplasm, congestive heart failure, bacterial endocarditis, or any other cardiovascular disease that is not suitable for inclusion; 5) Severe cardiopulmonary, liver or kidney dysfunction; 6) Abnormalities in the following laboratory studies: Orthidyl citrate transaminase or alanine aminotransferase higher than the normal upper limit of 3 times; Creatinine clearance rate 265umol / l (> 3.0mg / dl); 7) Patients with arterial dissection; 8) Intracranial hemorrhage occurred within 90 days before enrollment (cerebral parenchymal hemorrhage, subarachnoid hemorrhage, subdural / epidural hemorrhage); 9) History of intracranial tumors or cerebral aneurysms, arteriovenous malformations; 10) severe blood system diseases or severe coagulation dysfunction; 11) Retinal hemorrhage or visceral bleeding within 30 days; 12) Expected to undergo major surgery (including femoral artery, heart, aorta or carotid artery surgery) within 30 days prior to enrollment or within 12 months after enrollment; 13) Distant ischemic to adapt to taboo, such as upper limb there is more serious soft tissue injury, fracture or vascular injury, distal peripheral vascular disease; 15) Pregnant or nursing women; 16) Life expectancy <1 years; 17) Reluctant to be followed up or with poor compliance; 18) Are participating in other clinical trial, or or have participated in this study; 19) Other circumstances unsuitable for inclusion determined by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of depression in patients with acute ischemic stroke; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hamilton Depression Scale; | — |
Countries
China
Contacts
Haian county people's hospital affiliated to nantong university