cancer
Conditions
Interventions
Test groub :Apatinib +docetaxel
Sponsors
the First affiliated Hospital of SooChow University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged 18-75 years old, men and women; 2. The histopathological diagnosed III B or IV lung squamous carcinoma; 3. A line after treatment failure of chemotherapy of patients with advanced lung squamous carcinoma; 4. At least one measurable lesions, and distance great vessels > 5 mm (in accordance with the requirements of RECIST 1.1 the measurable lesions spiral CT scan length to diameter 10 mm or swollen lymph nodes or short diameter 15 mm or higher);The biggest tumor 10 cm or less; 5. ECOG PS 0 to 2 points; 6. Survival is expected or greater in March; 7. Major organs functioning;That meet the following criteria: (1) the blood routine examination should accord with a standard (no blood transfusion and adjuvant therapies within 14 days, unused and other hematopoietic stimulating factor (g-csf) correct): HB 80 g/L or higher; the ANC acuity 1.5*10^9/L; PLT acuity 80*10^9/L; (2) and biochemical examination must be in accordance with the following criteria: A. TBIL 45 ml/min. 8. Women of childbearing age should be carried out in the group of 7 days before the pregnancy test (serum), and the results were negative, and willing to during the trial and 8 weeks after the last gives the experimental drug USES the appropriate method of contraception.For men, should be sterilization surgery, or agreed to during the trial and 8 weeks after the last give experimental drug use of appropriate methods of contraception; 9. Willing to join in this study, subjects signed informed consent, good adherence, cooperate with the follow-up.
Exclusion criteria
Exclusion criteria: 1. People with high blood pressure and antihypertensive drug therapy can not drop to normal range (systolic blood pressure > 140 mmHg, diastolic blood pressure > 90 mmHg); 2. Always suffer from severe cardiovascular disease: II magnitude of myocardial ischemia and myocardial infarction, poor control of cardiac arrhythmias (including QTc interphase male 450, female 470 ms or ms or higher); According to NYHA standard, III~IV cardiac insufficiency, or heart colour to exceed revealed left ventricular ejection fraction (LVEF) 1.0 g); 4. The researchers think the respiratory tract may occur big haemoptysis; 5. Coagulant function abnormality (INR > 1.5, APTT ULN > 1.5), with bleeding tendency; 6. According to the researcher's judgment, there are other serious to endanger the safety of patients or patients with disease to do the research; 7. Patients with central nervous system metastasis; 8. Pregnant or lactating women; 9. Other researchers think that patients don't suitable for this test.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PFS; | — |
Secondary
| Measure | Time frame |
|---|---|
| ORR;OS;DCR; | — |
Countries
China
Contacts
Public ContactJiang Junhong
the First affiliated Hospital of SooChow University
Outcome results
None listed