The effects and mechanisms of PGE1 on cardiac fibrosis and angiogenesis during pressure overload

Status

Recruiting

Phases

Phase 4

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR-OPC-17011136

Enrollment

Unknown

Registered

2017-04-13

Start date

2017-04-15

Completion date

Unknown

Last updated

2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

heart failure

Interventions

PGE1 group:PGE1

control group:standard treatment

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: (1) the heart significantly dilated; (2) conforms to the diagnostic standard of chronic heart failure, LVEF < 40%, NYHA class III to IV.

Exclusion criteria

Exclusion criteria: (1) old myocardial infarction and ischemic heart disease; (2) renal insufficiency; (3) mechanical complications of coronary heart disease (ventricular septal perforation, papillary muscle dysfunction); (4) heart dilation and heart failure caused by end-stage cor pulmonale.

Design outcomes

Primary

Measure	Time frame
echocardiography;	—

Secondary

Measure	Time frame
NYHA grade;NT-proBNP;hs-CRP;Gal-3;procollagen III;TGF-b1;VEGF;	—

Countries

China

Contacts

Public ContactHonghui Wang

First Affiliated Hospital of Harbin Medical University

fairymhh@hotmail.com+86 0451-85555115

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026