lung cancer
Conditions
Interventions
Sponsors
Sir Run Run Shaw Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Histologically or cytologic confirmedNSCLC of stage IIIB or IV ,or Difficult to tolerate surgery or refused to accept the operation stage IIIA patients; 2. Single lung disease stove= 6, the maximum tumor diameter= 5 cm; 3. Aged 18 years and over; 4. Eastern Cooperative Oncology Group(ECOG)performance scale 0 - 2; 5. Life expectancy of more than 12 weeks; 6. Adequate hepatic, renal, heart, and hematologic functions (without blood transfusion during 14 daysunused g-csf and other hematopoietic stimulating factor correct) Absolute Neutrophil Count(ANC) = 1.5×10^9/L, Platelet (PLT) = 80×10^9/L, Hemoglobin(HB) = 90 g/L, ALB=29g/L (without ALB during 14 days); Aspartate transaminase(AST) and alanine transaminase (ALT)=5×ULN Cr=1.5×ULN, total bilirubin =1.5× ULN; 7. Signed and dated informed consent. Willingness and ability to comply with scheduled visits, treatment plans, laboratory tests, and other study procedure.
Exclusion criteria
Exclusion criteria: 1. Single lung disease stove>6, the maximum tumor diameter> 5 cm; 2. Patients with the lung lesions associated with a larger hole; 3. Lesions is adjacent to the main bronchus or pulmonary vascular, or central type lung cancer with severe obstructive pneumonia patients; 4. patients with A large number of pleural effusion; 5. patients have medical history of pulmonary fibrosis, interstitial pneumonia, pneumoconiosis, radioactive pneumonia, drug related pneumonia, pulmonary function was seriously damaged; 6. History of clinically significant haemoptysis =1.5 o rPT>Upper Limit of Normal(ULN)+4s or Activated Partial Thromboplastin Time (APTT) >1.5 Upper Limit Of Normal(ULN)), hemorrhagic tendency or receiving the therapy of thrombolysis or anticoagulation; 13. Symptomatic patients with central nervous system transfer; 14. Urine protein=++, or 24h urine protein quantitation=1.0g; 15. Pregnant or breast-feeding women; patients with fertility will not or there is no way to adopt effective contraceptive measures; 16. Patients with HIV infection; 17. Other conditions regimented at investigators' discretion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PFS; | — |
Secondary
| Measure | Time frame |
|---|---|
| OS;DCR;ORR;Safety; | — |
Countries
China
Contacts
Public ContactYong Fang
Sir Run Run Shaw Hospital
Outcome results
None listed