infertility caused by severe intrauterine adhesions or intrauterine scarring
Conditions
Interventions
bFGF injection group:hysteroscopy followed by injection of bFGF
Sponsors
The Affiliated Drum Tower Hospital of Nanjing University Medical School
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1) Infertile patients in accordance with WHO diagnostic standard of infertility; 2) Patients with intrauterine adhesions for whom drugs and surgical interventions were ineffective , including severe intrauterine adhesions or severe intrauterine scarring or thin endometrium; 3) Aged 20-40 years old; 4) With clear fertility desires; 5) Normal ovarian function or with frozen embryos; 6) Willing to actively cooperate with postoperative follow-up.
Exclusion criteria
Exclusion criteria: 1) With abnormal chromosome karyotype; 2) With other uterine diseases including large intramural myomas,severe endometriosis,severe adenomyosis,severe congenital uterine malformations, endometrial tuberculosis,vaginitis and endometritis 3) Systemic diseases: hypertension, diabetes, and so on; 4) Contraindications to pregnancy; 5) Contraindications to hormone replacement therapy; 6) Medical history of pelvic tumors or receiving pelvic radiotherapy; 7) Involved in other clinical study; 8) Unable to adhere to the follow-up, or carrying on other treatment during follow-up period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pregnancy rate;Recovery of impaired endometrium; | — |
Secondary
| Measure | Time frame |
|---|---|
| Endometrial thickness and blood flow;Menstruation; | — |
Countries
China
Contacts
Public ContactYali Hu
The Affiliated Drum Tower Hospital of Nanjing University Medical School
Outcome results
None listed