carotid artery stenosis
Conditions
Interventions
Treatment group:Edaravone
Sponsors
Department of Vascular and Endovascular Surgery ChangZheng Hospital, Affiliated Hospital of the Sencond Military Medical University No.415 FengYang Rd HuangPu Shanghai China PR.
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Patients with definite diagnosis of carotid stenosis; 2. Indications for surgery, reference to American cardiac surgery guidelines AHA and European guidelines for vascular surgery ESVS 3. Exclusion of taboo; 4. Informed consent form signed by the legal representative of the patient or patient.
Exclusion criteria
Exclusion criteria: 1. Pregnancy or perinatal period; 2. Suffering from severe heart, lung and other primary diseases, liver and renal insufficiency (ALT, AST above the normal limit of 2 times or more than the normal value of serum creatinine is more than 2 times), or severe secondary infection; 3. After the onset of neuroprotective agents have been used to treat, including ganglioside, cell two choline phosphate, piracetam, Ding Ji, etc.; 4. Patients with severe mental illness or dementia, poor treatment compliance; 5. The edaravone allergy; 6. Unable to cooperate with, unable to sign informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hyperperfusion syndrome; Secondary cerebral infarction;Secondary cerebral hemorrhage;Serum S100beta;Serum MMP-9;Serum IL-1a;Serum TNF; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative cognitive dysfunction; | — |
Countries
China
Contacts
Public ContactLefeng Que
ChangZheng Hospital
Outcome results
None listed