Intracranial atherosclerotic stenosis
Conditions
Interventions
Two cohorts:intensified dose of rosuvastatin (20 mg/day, 52 weeks) versus standard dose of rosuvastatin (10 mg/day, 52 weeks)
Sponsors
The Second Affiliated hospital of Zhejiang University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Sign the informed consent form before the study begins; (2) men or women between the ages of 18-80; (3) stroke or transient ischemic attack in the last three months; (4) intracranial artery (intracranial carotid artery, middle cerebral artery, basilar artery, vertebral artery) stenosis degree of 50-99%; (5) No statin therapy was used within 3 months before enrollment.
Exclusion criteria
Exclusion criteria: Same as the hospital clinical research. (1) any hemorrhagic stroke or hemorrhagic infarction; (2) any cardiogenic embolism; (3) extracranial carotid artery stenosis (> 50%) with symptomatic intracranial stenosis; (4) other vascular diseases, such as: arterial dissection, vasculitis, vascular spasm, dissecting aneurysm, radiation-induced vascular disease, (5) the target area has undergone stenting, angioplasty or other mechanical device treatment or planned 2 years of angioplasty therapy; (6) severe neurological deficits caused by patients with independent living ability; (7) life expectancy of patients less than 2 years; (8) Known or suspected to be allergic to a study drug or its equivalent; (9) must take the following drugs: hormones, cyclosporine and other lipid-lowering drugs: cod liver oil, fiber acids, nicotinic acid, probucol; (10) the researchers believe that there are other clinical disease affecting the patient to complete the trial; (11) ALT or AST> 3 times the normal high, serum creatinine> 2.0 mg / dL, GFR <30 mL / min, or findings of clinical significance by the investigator; (12) Ladies who are pregnant during pregnancy, lactation, and who are not likely to take any contraceptive measures.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood lipid;Nerve function score; | — |
Countries
China
Contacts
Public ContactDai haibin
The Second Affiliated hospital of Zhejiang University School of Medicine
Outcome results
None listed