multi-drug resistant pulmonary tuberculosis
Conditions
Interventions
initial treatment faliure of MDR-PTB:thymosin as adjuvant treatment
retreament MDR-PTB:thymosin as adjuvant treatmen
Sponsors
Shanghai Pulmonary Hosptial, Tongji University School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Adult patients with active pulmonary tuberuclosis, aged 18-65 years old, satisfied with the following conditions will be included: 1. hospitalized patients with active PTB,sputum smear acid fast staining positive or sputume culuture positive, and DST showing at least resistant to isoniazid and rifampin, MDR-PTB; 2. acquired informed consent of hospital ethic commettee and patients who would like to participate in this study.
Exclusion criteria
Exclusion criteria: patients satisfied with any conditions as follows will be exclued from this study: isolation bacterium identified as non-mycobacterium tuberulosis; severe adverse effects against anti-TB drugs, severe liver and renal dysfunction, poor blood gulcose level, complicated by HIV/AIDS, cancer, immune function disorders, pregant and children, elders more than 65 years old.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| negative rate of sputum culture; | — |
Secondary
| Measure | Time frame |
|---|---|
| lesion obsorption rate;cavity close rate;change of CD3 and CD4; | — |
Countries
China
Contacts
Public ContactFan Lin
Shanghai Pulmonary Hosptial, Tongji University School of Medicine
Outcome results
None listed