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Activation of adenosine A2A receptor after traumatic brain injury accelerates phospho-tau protein propagatoin and working memory dysfunction

Activation of adenosine A2A receptor after traumatic brain injury accelerates phospho-tau protein propagatoin and working memory dysfunction

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR-OPC-16008982
Enrollment
Unknown
Registered
2016-08-05
Start date
2016-08-01
Completion date
Unknown
Last updated
2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

traumatic brain injury

Interventions

traumatic brain injury:surgical removal of perihematomal brain tissue

Sponsors

Research Institute of Surgery and Daping Hospital, the Third Military Medical University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Patients hospitalized for severe TBI with potentially fatal hematoma require emergent surgical treatment to reduce intracranial pressure.

Exclusion criteria

Exclusion criteria: Patients whit mild traumatic brain injury and don't need emergent surgery.

Design outcomes

Primary

MeasureTime frame
tau protein;adenosine A2A receptor;PKA;GSK-3ß;KIF2A;—

Countries

China

Contacts

Public ContactYuan-Guo Zhou

Molecular Biology Center, State Key Laboratory of Trauma, Burn, and Combined Injury, Research Institute of Surgery and Daping Hospital, Third Military Medical University

yuanguo.zhou@gmail.com+86 023 68757471

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026