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Conditions
Interventions
Experimental:Patients received the following quintuple therapy for 7 days: bismuth subcitrate 220 mg bid,Esomeprazole 20 mg bid, clarithromycin 500 mg bid., amoxicillin 1 g bid, and metronidazole 500
Sponsors
The First Affiliated Hospital of Nanchang University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 70 years, both female and male; 2. the helicobacter pylori positive patients with chronic gastritis or no complications of peptic ulcer; 3. did not receive H. pylori eradication therapy prior to enrollment; 4. signed informed consent.
Exclusion criteria
Exclusion criteria: 1. patients who were treated with antibiotics, bismuth agent, H2 receptor antagonist (H2RA), PPI or a mucosa protective agent two weeks before enrollment; 2. patients with gastric ulcers and esophageal ulcers; 3. patients who were pregnant or lactating; 4. patients with other serious diseases, such as severe liver, heart and kidney disease, cancer and disorders caused by alcohol abuse; 5. known allergy to drugs being prescribed; 6. patients who participated in other drug research during the 3 mo prior to enrollment; 7. patients who could not correctly express their complaints, such as those who had a mental illness, severe nervous functional disorders, or could not cooperate with researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| eradication rate of helicobacter pylori infection; | — |
Secondary
| Measure | Time frame |
|---|---|
| symptom remission rate; | — |
Countries
China
Contacts
Public ContactNonghua Lv
The First Affiliated Hospital of Nanchang University
Outcome results
None listed