epilepsy
Conditions
Interventions
rapid metabolism:sodium valproate 0.4 q12h
poor metabolism:sodium valproate 0.4 q12h
Sponsors
Huahan Hospital, Fudan University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age 16-65, male or female; 2. GCS 4-10, or GCS progressively decrease to 4-10; 3. Closure head injury; 4. Hemodynamic stable prior to enrollment, the systolic blood pressure> 110 mm Hg, diastolic blood pressure> 60 mm Hg, 5. heart rate <120 beats/min; 6. Conservative treatment of patients served within 24 hours after injury, surgical patients carry out surgery within 24 hours.
Exclusion criteria
Exclusion criteria: 1. Pregnant women; 2. Sedation treatment is necessary; 3. Just a short coma after injury, when the ambulance arrived at the scene or in hospital the patients turned clear consciousness; 4. Open brain injury or penetrating trauma; 5. Systolic blood pressure 120 beats / min, and cannot be corrected within 30 minutes; 6. Bilateral mydriasis with no light reflex; 7. Other parts of the body trauma AIS score> = 4; 8. Persistent hypoxemia (oxygen saturation <94% and greater than 30 minutes); 9. Unable to carry out neurophysiological monitoring after admission or surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| serum valproate concentration;seizure attack;prognosis (GOS); | — |
Countries
China
Contacts
Public ContactYirui
Outcome results
None listed