Acute left lower extremity deep vein thrombosis
Conditions
Interventions
A:balloon-assisted catheter directed thrombolysis, stents will be implanted after thrombosis completely dissolved
B:balloon-assisted catheter directed thrombolysis, stent will be implanted simultaneously.
Sponsors
The First Affiliated Hospital of Soochow University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Men and women between 18–75 years of age; (2) Symptoms last for less than 14 days(patients with history of lower limb swelling should be excluded); (3) Definite diagnosis of left lower extremity deep vein thrombosis(central or mixed type) combined with iliac vein stenosis by ultrasonography or angiography. Complementary inclusion: iliac vein stenosis diagnosed by balloon dilatation; (4) Patients understand the nature of the procedure, cooperate with follow-up, and provide written informed consent before enrollment in the study.
Exclusion criteria
Exclusion criteria: (1) Patients with anticoagulation of more than 7 days; (2) Patients with uncorrected bleeding disorders (portal hypertension, gastrointestinal bleeding, gastrointestinal ulcer); (3) Hemoglobin < 8 g/dL; (4) Platelet < 80*10^9/L; (5) Severe renal failure, Ccr < 30ml/min; (6) Severe hypertension (diastolic blood pressure greater than 100 mm Hg, systolic blood pressure greater than 160 mm Hg); (7) DVT complicating pregnancy or with recent (<14 days) childbirth; (8) Women with child-bearing potential should be confirmed unpregnant by urine pregnancy test; (9) Patients with recent (<14 days) major surgery or trauma; (10) Patients with recent (<3 months) subdural hemorrhage or intracranical hemorrhage; (11) Life expectancy of less than 24 months; (12) Patients with a history of homolateral DVT; (13) Patients with an extensive iliac vein stenosis or stale thrombus in the secondary enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Rate of lower extremity swelling relief;Rate of vein patency;Post-thrombotic syndrome;VEINES-QOL/Sym questionnaire;Dosage of urokinase;Time of thrombolysis catheter indwelling (treatment time);Hospitalization expenses; | — |
Countries
China
Contacts
Public ContactNi Caifang
Outcome results
None listed