gastrointestinal stromal tumors
Conditions
Interventions
preoperative IM treatment group:preoperative IM treatment
Sponsors
Department of gastrointestinal surgery, West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Abdominal CT show that giant mass located in abdominal cavity (tumor size >=10cm); 2. All tumors were acquired by endoscopic ultrasound-guided fine-needle aspiration biopsy or needle biopsy guided by abdominal CT and pathologically diagnosed as GIST, and the patients aged from 18 to 80 years old; 3. All patients take imatinib as preoperative therapy; 4. Patients were informed, and voluntarily signed the informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with huge gastrointestinal stromal tumors refused preoperative imatinib therapy; 2. Pregancy or the ones who were alleric to imatinib; 3. Patients who take imatinib irregularly, and medication duration was fewer than 28 days.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Plasma concentration of Imatinib;Clinical efficacy; | — |
Secondary
| Measure | Time frame |
|---|---|
| liver/renal function, serum biochemical index; | — |
Contacts
Public ContactZhang Bo
Outcome results
None listed