gastroesophageal reflux disease
Conditions
Interventions
Case series:Nil
Sponsors
the first affiliated hospital of SYSU
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Consecutive patients aged 18–65 years who go to the gastroenterology clinic presented with upper gastrointestinal discomfort, such as the following symptoms: heartburn, regurgitation, dysphagia, substernal pain, epigastric pain, epigastric burning, early satiety, postprandial fullness; 2. The previous symptoms should last for at least 3 months; 3. The frequency of the previous symptoms should be at least 3 days per week with moderate severity; 4. Able to fill inthe questionaires (see attachment).
Exclusion criteria
Exclusion criteria: 1. Patients with gastric or duodenal ulcers, upper GI neoplasms on upper endoscopy; 2. Patients with severe cardiac or pulmonary diseases, diabetes or rheumatic diseases; 3. Patients with a history of operations in the upper GI tract; 4. Patients with renal failure or abnormal liver function; 5. Patients with use of non-steroidal anti-inflammatory drugs (NSAIDs); 6. Patients who are allergy to esomeprazole; 7. Pregnancy or lactating mother.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the primary symptom of GERD in Chinese outpatients in Gastroenterology department; | — |
Secondary
| Measure | Time frame |
|---|---|
| The percentage of each symptom of GERD;The life quality of GERD patients;the sensitivity and speicificity of either GERD Q or 4-week PPI test for diagnosis of GERD; | — |
Countries
China
Contacts
Public ContactChen Minhu
Outcome results
None listed