Co-transfer umbilical cord blood to prevent primary graftment failure in the non in vitro T cells depleted haploid transplantation and its mechanism

Conditions

hematological malignancies

Ma N, Wu WB, Zhao XY, Xu LP, Zhang XH, Wang Y, Mo XD, Zhang YY, Zhao XS, Sun YQ, Cheng YF, Liu KY, Chang YJ, Huang XJ.

2024-04-013 citations

10.3324/haematol.2023.283698

Rituximab for desensitization during HLA-mismatched stem cell transplantation in patients with a positive donor-specific anti-HLA antibody.

Chang YJ, Xu LP, Wang Y, Zhang XH, Chen H, Chen YH, Wang FR, Han W, Sun YQ, Yan CH, Tang FF, Huo MR, Zhao XY, Mo XD, Liu KY, Huang XJ.

2020-05-0841 citations

10.1038/s41409-020-0928-z

Rituximab for Desensitization during HLA-Mismatched Stem Cell Transplantation in Patients with a Positive Donor Specific Anti-HLA Antibody: A Prospective Study

Ying‐Jun Chang, Lan‐Ping Xu, Yu Wang, Xiaohui Zhang, Huan Chen et al. (16 authors)

Blood2019-11-13

10.1182/blood-2019-129781

Class I and II human leukocyte antibodies in pediatric haploidentical allograft candidates: prevalence and risk factors.

Lv M, Zhai SZ, Wang Y, Xu LP, Zhang XH, Chen H, Chen YH, Wang FR, Han W, Sun YQ, Cheng YF, Yan CH, Mo XD, Liu KY, Chang YJ, Huang XJ, Zhao XY.

2019-01-1711 citations

10.1038/s41409-018-0427-7

Interventions

testing ???:no

Eligibility

Sex/Gender

All

Age

2 Years to 60 Years

Inclusion criteria

Inclusion criteria: Patients with hematological malignancies who need allogeneic stem cell transplantation and plan to undergo haploid transplantation; The mean fluorescence intensity of donor specific antigen of the patients's serum is above or equal to 2000 and less than 10000.

Exclusion criteria

Exclusion criteria: 1) patients who are not able to regular follow-up; 2) patients in other clinical trails.

Design outcomes

Primary

Measure	Time frame
engraftment time;	—

Secondary

Measure	Time frame
Overall Survival;	—

Countries

China

Contacts

Public ContactXiaoJun Huang

huangxiaojun@bjmu.edu.cn+86 010 88324577

Outcome results

None listed