infertility caused by severe intrauterine adhesions
Conditions
Interventions
collagen scaffold loaded with umbilical cord blood :hysteroscopy adhesiolysis followed by collagen scaffold loaded with umbilical cord blood-derived mesenchymal stem cells treatment
Sponsors
The Affiliated Drum Tower Hospital of Nanjing University Medical School
Eligibility
Sex/Gender
Female
Age
22 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. patients with severe intrauterine adhesions or scarring of the endometrium for whom drugs and surgical interventions were ineffective; 2. Age: 22-45 years old; 3. who is willing to accept follow-up.
Exclusion criteria
Exclusion criteria: 1. Chromosome karyotype abnormalities; 2. Severe endometriosis; 3. Severe adenomyosis; 4. Severe congenital uterine malformations; 5. Vaginitis and endometritis; 6. systemic diseases: hypertension, diabetes, and so on; 7. Contraindications to pregnancy; 8. Contraindications to hormone replacement therapy; 9. Medical history of pelvic tumors or receiving pelvic radiotherapy; 10. Unable to adhere to the hospital examination and follow-up, or carrying on other treatment during follow-up period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Menstruation;Endometrial thickness and blood flow;Endometrial recovery status;Conception; | — |
Secondary
| Measure | Time frame |
|---|---|
| Prenatal care; | — |
Countries
China
Contacts
Public ContactYali Hu
Outcome results
None listed