Chronic Hepatitis B
Conditions
Interventions
Alone group:nucleoside (acid) analogues
Sponsors
First Affiliated Hospital of Xinjiang Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Chronic Hepatitis B infection based on diagnostic criteria of 2015 China clinical practice guidelines of chronic hepatitis B (updated); 2. Males or females with age from 18 to 65 years old, capable of signing the informed consent; 3. Persistently positive HBsAg for more than 6 months,HBV-DNA is postive and liver function is normal or less than twice the upper limit of normal; 4. Histology of liver biopsy is less than G2S2 or LSM=9.0KPa.
Exclusion criteria
Exclusion criteria: 1. Abdominal ultrasonography or CT indicate hepatocellular carcinoma; 2. Coinfection by hepatitis B virus, hepatitis C virus (Hepatitis C RNA positive), hepatitis D virus and human immunodeficiency virus (HIV) positive patients; 3. Suffered from drug-induced hepatitis,fatty liver disease,alcoholic liver disease, autoimmune hepatic disease and inherited metabolic liver disorders; 4. Combination with carcinoma, severe cardiopulmonary disease, connective tissue disease and organ transplantation patients; 5. Treating with nucleoside (acid) analogues before inclusion; 6. Poor compliance or information missing which may affect efficacy and safety.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HBV-DNA;Liver function;Renal function;serum marker for heptitis B;hepatosplenic ultrasonic examination; | — |
Secondary
| Measure | Time frame |
|---|---|
| Liver stiffness measurement; | — |
Countries
China
Contacts
Public ContactLihua SUN
First Affiliated Hospital of Xinjiang Medical University
Outcome results
None listed