Rheumatoid Arthritis
Conditions
Interventions
RA group1:Doxycycline
RA group 2:Placebo
Sponsors
Hong Kong Baptist University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Around 100 RA patients from Guanghua Integrative Medicine Hospital in Shanghai will be selected to participate if they met the American College of Rheumatology (ACR) criteria for RA for at least one year and around 100 age- and gender-matched healthy subjects will also involved as control group. Healthy volunteers from Guanghua Integrative Medicine Hospital in Shanghai had participated in this study. Written informed consent will be obtained from all participants or their legal representatives before enrollment in the study. The study protocol is granted by the local Ethical Committee for Clinical Research.
Exclusion criteria
Exclusion criteria: Patients continuously receiving non-steroidal anti-inflammatory drugs, corticosteroids for over 6 months, or receiving the mentioned above medicine with one month will not be included in the study. Patients with severe cardiovascular, lung, liver, kidney, hematologic, or mental disease and women who were pregnant, breast-feeding, or planning to become pregnant in the next 8 months will be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Metagenomic;Metabolomics; | — |
Countries
China
Contacts
Public ContactWu Xiaohao
Outcome results
None listed