Immune Thrombocytopenia
Conditions
Interventions
one:Corticosteroids
two:Corticosteroids combined with Cyclosporin A
Sponsors
Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged between 18 and 65, male or female; 2. Primary ITP patients diagnosed with consensus of Chinese experts on the diagnosis and treatment of adult primary immune thrombocytopenia (version 2016); 3. Platelet counts at enrollment <30*10^9/L
Exclusion criteria
Exclusion criteria: Subjects will be excluded if they have any of the following conditions: malignancy, connective tissue diseases, seropositive detection of human immunodeficiency virus, detectable HBV DNA, detectable HCV RNA, pregnancy or lactation, active infection that can't be controlled by antibiotics, uncontrolled hypertension (blood pressure is still higher than 140 / 90mmHg after taking oral antihypertensive agents), diabetes, New York Heart Association functional classes III and IV, active peptic ulcer, adrenocortical hyperfunction, during the recovery phase of trauma, ALT or AST is more than 2.5 times the upper limit of normal, total bilirubin is more than 1.5 times the upper limit of normal, renal insufficiency (elevated serum creatinine, hyperkalemia), psychosis, patients who are intolerant to corticosteroids or cyclosporin A, other situations not approved by researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Platelet counts; | — |
Secondary
| Measure | Time frame |
|---|---|
| Tregs subsets; | — |
Countries
China
Contacts
Public ContactDonghua Zhang
Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed