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Study on the antidepressant mechanism of morinda officinalis oligosaccharides

Study on the antidepressant mechanism of morinda officinalis oligosaccharides

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR-OON-17012050
Enrollment
Unknown
Registered
2017-07-19
Start date
2015-08-07
Completion date
Unknown
Last updated
2017-07-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dpression

Interventions

single group:administration of Morinda officinalis oligosaccharides

Sponsors

Peking University Sixth Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1. the patient was diagnosed as depressive episode according to ICD-10; 2. aged 18-65 years, dextromanuality, female or male; 3. the total scores of HAMD =18, =28; 4. signed the ICF.

Exclusion criteria

Exclusion criteria: 1. suicide history, allergic history for Morinda officinalis; 2. combined severe or unstable somatic disease; 3. the patient was diagnosed as epilepsy, bipolar affective disorder, drug or alcohol dependence; 4. the patient was in the MECT treatment now or took antidepressants during last 3 months; 5. the patients had some contraindications that limit them from taking MR examination; 6. pregnant or lactational patients.

Design outcomes

Primary

MeasureTime frame
BDNF;GDNF;VEGF;IGF;MDA;SOD;CAT;ACTH;CRH;5-HT;NE;DA;A;T-AOC;Cor;17-OHCS;24hUFC;IL-6;TNF-a;FSH;LH;E2;T;PRL;PRG;T3;T4;FT3;FT4;TSH;—

Countries

China

Contacts

Public ContactHongyan Zhang

Peking University Sixth Hospital

sally_zhy@sina.com+86 010-82801940

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026