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The correlation between oxidative stress with the occurrence and development of hepatic failure and the effects of artificial liver plasma exchange on oxidative stress

The correlation between oxidative stress with the occurrence and development of hepatic failure and the effects of artificial liver plasma exchange on oxidative stress

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR-OON-16010266
Enrollment
Unknown
Registered
2016-12-27
Start date
2017-01-01
Completion date
Unknown
Last updated
2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

HBV-related liver failure

Interventions

HBV-related ACLF group:artificial liver plasma exchange
HBV-related CLF group:artificial liver plasma exchange
Chronic hepatitis B group:without artificial liver plasma exchange
HBV-related decompensated cirrhosis group:without artificial liver plasma exchange

Sponsors

Ningbo No.2 Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 90 Years

Inclusion criteria

Inclusion criteria: The diagnosis is according to The prevention and treatment of viral hepatitis,The guideline of prevention and treatment for chronic hepatitis B (2015 version),Guideline for diagnosis and treatment for liver failure.

Exclusion criteria

Exclusion criteria: 1. Patient with HAV HCV HDV HEV and so on co-infection; 2. Patient who have autoimmune liver disease, alcoholic or non-alcoholic fatty liver disease and metabolic liver disease; 3. Patient with active bleeding or DIC; 4. Patient who is severe allergic to blood products or drugs such as plasma, heparin and protamine; 5. Patient who is hemodynamic instability; 6. Patient who is inunstability heart infarction caused by cerebrovascular accident; 7. Extravascular hemolysis; 8. Severe septicopyemia.

Design outcomes

Primary

MeasureTime frame
advanced oxidation protein products;glutathione peroxidase;superoxide dismutase;Vitamin E;C-reactive protein;

Countries

China

Contacts

Public ContactAirong Hu

Ningbo University

huairong6666@126.com+86 13968369377

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026