Chronic hepatitis B
Conditions
Interventions
Group A:Peg-IFN therapy
Group B :Nothing
Sponsors
Shenzhen TCM Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Adults between 18 and 60 years old; 2. HBV DNA <20000 IU/mL, HBeAg negative for more than 6 months, HBsAg positive and =1000IU/ml, ALT <2 ULN; 3. Previous treatment including IFN treatment less than 3 months was permitted, but not within the six months before the study; 4. No liver cirrhosis; 5. Informed consent was obtained from each patient included in the study.
Exclusion criteria
Exclusion criteria: coinfection with hepatitis A,C,D,E or HIV; white blood cell count<1,500/mm3, platelet count<90,000/mm3; history of pre-existing medical conditions such as severe psychiatric illness, retinopathy, neoplasm(active or likely to recur), seizure disorder, unstable thyroid dysfunction, and cardiac or renal disease; current pregnancy or breastfeeding of infants; alcohol/drug dependence within the previous 12 months;therapy with systemic antineoplastic or immunomodulatory agents within the past 6 months, or the administration of antiviral or investigationalcompounds within the past 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HBV DNA;HBsAg;HBsAb;HBeAg;HBeAb; | — |
Countries
China
Contacts
Public ContactTong Guangdong
Shenzhen TCM Hospital
Outcome results
None listed