Moderate and severe thyroid related ophthalmopathy
Conditions
Interventions
traditional treatment group:Give intravenous glucocorticoid treatment for three days, the first day of 500 mg, 250 mg, 250 mg on the third day the next day, once a month, a course in April, glucocorti
new treatment group 1:Once a week, 500 mg, for 6 weeks, then once a week, 250 mg, for six weeks, glucocorticoid total 4500 mg
new treatment group 2:Once a week, 500 mg, six weeks in a row, then once a week, 250 mg, six weeks in a row, add 0.2 cyclophosphamide use once a week at the same time, glucocorticoid total 4500 mg
Sponsors
The sencond hospital of huaian, Jiangsu
Eligibility
Sex/Gender
Male
Age
20 Years to 70 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: according to the China a shaped gland disease disease clinical governance refers to the south (Graves' eye disease department points) correlation diagnosis of thyroid eye disease, and according to the EUGOGO score, diagnosis of patients with moderately severe eye diseases.Diagnostic criteria: patients need to have the following at least one performance: contracture in the cap of 2 mm more than the reference range, eyelids or severe soft tissue damage, exophthalmos degree more than 3 mm, exceeding the maximum limit reference range and persistent diplopia.Material feeding patients after ultrasound of thyroid lesions, including diffuse goiter, nodules, adenoma, and so on.And there are eye disease
Exclusion criteria
Exclusion criteria: Exclude space-occupying lesions after eye, eye of primary diseases such as glaucoma.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| sICAM-1; | — |
Countries
China
Contacts
Public ContactWen Hu
Outcome results
None listed