Polycystic ovary syndrome
Conditions
Interventions
intensive lifestyle intervention group (over weight):Low GI diet + Motion
GLP-1 group (over weight):GLP-1
metformin group (over weight):metformin
acarbose group (over weight):acarbose
normal weight:Low GI diet + Motion/GLP-1/metformin/acarbose
Sponsors
Shanghai Jiaotong University School of Medicine, Renji Hospital Department of Endocrinology and Metabolism
Eligibility
Sex/Gender
Female
Age
14 Years to 40 Years
Inclusion criteria
Inclusion criteria: Overweight and obese PCOS patients with newly diagnosed IGT; PCOS diagnosis based on 1990 NIH criteria. Overweight / obesity diagnostic criteria according to WHO-WPR. IGT diagnostic criteria according to 1998 WHO diagnostic criteria.
Exclusion criteria
Exclusion criteria: Except for serious complications (cardiovascular events and recent significant kidney or lung disease within 3 months), and had high blood pressure (>160/100mmHg), blood sugar and high blood lipids (glycated hemoglobin> 11%, triglycerides >600 mg/dl).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| OGTT Glucose;OGTT Insulin;Hyperglycemic clamp Insulin;GLP-1;Glucagon;HOMA-IR;HOMA-beta;Body fat content outcome measurements assessed by MRI;polycystic ovary assessed by ultrasounds;sex hormones; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cholesterol;Triglyceride;Low Density Lipoprotein;High Density Lipoprotein;Weight;Body Mass Index;Waistline;Hipline;Blood chemistry for liver function;Blood chemistry for kidney function;blood routine;serum Cortisol;Thyroid function; | — |
Countries
China
Contacts
Public ContactTao Tao
Outcome results
None listed