Hypertension and Obesity
Conditions
Interventions
five-groups:no
Sponsors
TCM Hospital of Xinjiang Autonomous Region
Eligibility
Sex/Gender
All
Age
40 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Hypertension with obesity group (1) comply with hypertension with obesity diagnostic criteria: Obesity occurs before hypertension; BMI more than 28Kg/m2; SBPhigher than 140mmHg or DBP higher than 90mmHg; (2) to be aged from 40 years to 65 years; (3) Signed informed consent. 2. Obesity group (1) BMI more than 28Kg/m2; (2) No hypertension; (3) to be aged from 40 years to 65 years; (4) Signed informed consent. 3. Healthy control group: (1) BMI from 18.5Kg/m2 to 24Kg/m2; (2) No hypertension; (3) to be aged from 40 years to 65 years; (4) Signed informed consent. 4. Hypertension without obesity group: (1) BMI between 18.5Kg/m2 to 24Kg/m2; (2) hypertension; (3) to be aged from 40 years to 65 years; (4) Signed informed consent. 5. Cushing's syndrome group: (1) If the clinical manifestations consistent with CS, the 24h-UFC more than 5 times of upper limit of normal, no other checks can be confirmed. Results suspicious, to be 48h-LDDST confirmed; (2) late-night salivary more than 4 nmol/L (145 ng/dL); (3) midnight plasma cortisol more than 50 nmol/L (1.8 mg/dL); such less than 1.8 mg/dL, can be excluded CS; (4) overnight 1mg-LDDST serum cortisol more than 1.8 mg/dL; (5) Signed informed consent.
Exclusion criteria
Exclusion criteria: 1. With severe heart and brain and kidney and hematopoietic system diseases; 2. Mental disorders, with anxiety, depression, those with no insight, who can not express; 3. Other patients participating in clinical trials; 4. Not signed informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Salivary cortisol;blood pressure;BMI; | — |
Secondary
| Measure | Time frame |
|---|---|
| blood lipids;glucose; | — |
Countries
China
Contacts
Public ContactXu Hongfeng
Outcome results
None listed