cough variant asthma
Conditions
Interventions
Two groups:budesonide/formoterol
Sponsors
Second Affiliated Hospital, Zhejiang University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. All subjects agreed to participate, understand the project, observe the use of drugs, agree to follow-up, and signed informed consent; 2. aged 18 to 70 years old male and female; 3. The duration time was more than 8 weeks,and cough was usually the only complaint, without breathing, short of breath, chronic cough.Often accompanied by irritant cough at night and (or) in the early morning. Aggravated after exercise. 4. A diagnosis of asthma supported by one or more other characteristics: (1) bronchial provocation test positive; (2) improvement in FEV1 of more than 12% and 200 mL after inhaled salbutamol; (3) variability in diurnal peak expiratory flow (PEF) of more than 10% for one day during one week. 5. Bronchodilator and glucocorticoid treatment is effective.
Exclusion criteria
Exclusion criteria: 1. Can not cooperate with related inspection or for other reasons; 2. Patients with chronic obstructive pulmonary disease, interstitial pneumonia, active tuberculosis, community acquired pneumonia, lung cancer, bronchiectasis, cor pulmonale, pulmonary embolism, and companied with serious systematic disease (such as coronary heart disease, myocarditis, heart failure, GERD, neuromuscular disease, etc); 3. History of drug abuse, alcohol abuse or anesthesia or with a history of mental illness (schizophrenia, obsessive-compulsive disorder, depression) and against personality, motivation, suspicious, or other emotional or mental issues that may affect participation in the study; 4. taking part in other drug clinical trial project, or drop out less than 3 months; 5. during pregnancy, lactation women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| daily cough symptom score; | — |
Secondary
| Measure | Time frame |
|---|---|
| LCQ life quality score;the improvement of pulmonary function;ER/ hospital visits for uncontrolled cough;Acute episoded cough; | — |
Countries
China
Contacts
Public ContactWen Li
Second Affiliated Hospital, Zhejiang University School of Medicine
Outcome results
None listed