bone and soft tissue sarcoma
Conditions
Sponsors
Beijing Jishuitan Hospital; 81th Hospital of PLA; Dongfang Hospital Affiliated to Shanghai Tongji University
Eligibility
Sex/Gender
All
Age
8 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Aged 8 to 75 years old, male and female; (2) bone and soft tissue sarcoma diagnosed by histopathological examination, and patients with advanced stage of sarcoma treated with systemic treatment and failure of first-line treatment; (3) capable of obtaining sufficient amounts of fresh tumor tissue (surgical resection or biopsy to obtain primary or metastatic foci); (4) all patients should have measurable lesions, and the efficacy evaluation should be evaluated by RECIST 1.1 standard; (5) ECOG score 02, expected survival should be more than 3 months; (6) anticancer drugs (previous chemotherapy and / or targeted therapy) were enrolled in the study from the last time should be over 2 weeks; (7) the participants volunteered to sign the informed consent and had good compliance. They were able to actively treat and cooperate with the follow-up.
Exclusion criteria
Exclusion criteria: (1) participate in clinical study of other drugs; (2) liver and renal function and hematopoietic function of bone marrow do not meet the requirements of chemotherapy; (3) reluctant to undergo subsequent chemotherapy after the failure of the previous treatment using the anticancer drugs or protocols recommended by the researchers in conjunction with the test results; (4) those suffering from severe uncontrolled acute infection or major organ disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ORR;PFS;OS; | — |
Countries
China
Contacts
Public ContactNiu Xiaohui
Beijing Jishuitan Hospital
Outcome results
None listed