Chronic Obstructive Pulmonary Disease
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. Aged 18-75 years old, living in the appropriate follow-up study center area; 2. COPD: Clinical features (smoking history, cough, sputum, dyspnea, etc.), the disease is stable, FEV1/FVC% <70%; 3. Healthy subjects: age, sex matched with COPD patients, no smoking or smokers, chest X-ray normal, no acute, chronic disease or in a good state of control; 4. Annual residence in the permanent residence of not less than 9 months; 5. To be able to write or talk; 6. During the monitoring period, it is willing to carry the air monitor and fill the air fine particle monitoring log register; 7. Sign informed consent voluntarily.
Exclusion criteria
Exclusion criteria: 1. The presence of major diseases other than COPD, such as pulmonary malignancies, heart failure, renal failure, dementia and so on; 2. COPD was last within four weeks of severe acute exacerbation; 3. Blood ALT or AST more than 2 times the upper limit of normal, blood Cr above the upper limit of 1.5 times the normal value; 4. HIV Positive; 5. Within 3 months of acute cardiovascular and cerebrovascular events (stroke, transient ischemic attack, acute coronary syndrome); 6. History of incomplete neoplasms; 7. Mental illness, drug addiction or alcohol abuse; 8. Breastfeeding, pregnancy or recent planned pregnancy; 9. Not suitable for follow-up of subjects; 10. Subjects who are not expected to cooperate; 11. Those who have a basic disease life expectancy of less than 2 years.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pulmonary Function Tests; | — |
Countries
China
Contacts
The First Affiliated Hospital, Guangzhou Medical University