Skip to content

Correlative cohort study on the effect of air fine particles on pulmonary function and acute exacerbation in patients with chronic obstructive pulmonary disease

Study on the mechanism of airway remodeling protein and non-coding nucleic acid regulatory network from different sources of atmospheric fine particles

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR-OOC-17011941
Enrollment
Unknown
Registered
2017-07-11
Start date
2017-08-01
Completion date
Unknown
Last updated
2017-07-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Obstructive Pulmonary Disease

Interventions

COPD:No
Control:No

Sponsors

Guangzhou Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Aged 18-75 years old, living in the appropriate follow-up study center area; 2. COPD: Clinical features (smoking history, cough, sputum, dyspnea, etc.), the disease is stable, FEV1/FVC% <70%; 3. Healthy subjects: age, sex matched with COPD patients, no smoking or smokers, chest X-ray normal, no acute, chronic disease or in a good state of control; 4. Annual residence in the permanent residence of not less than 9 months; 5. To be able to write or talk; 6. During the monitoring period, it is willing to carry the air monitor and fill the air fine particle monitoring log register; 7. Sign informed consent voluntarily.

Exclusion criteria

Exclusion criteria: 1. The presence of major diseases other than COPD, such as pulmonary malignancies, heart failure, renal failure, dementia and so on; 2. COPD was last within four weeks of severe acute exacerbation; 3. Blood ALT or AST more than 2 times the upper limit of normal, blood Cr above the upper limit of 1.5 times the normal value; 4. HIV Positive; 5. Within 3 months of acute cardiovascular and cerebrovascular events (stroke, transient ischemic attack, acute coronary syndrome); 6. History of incomplete neoplasms; 7. Mental illness, drug addiction or alcohol abuse; 8. Breastfeeding, pregnancy or recent planned pregnancy; 9. Not suitable for follow-up of subjects; 10. Subjects who are not expected to cooperate; 11. Those who have a basic disease life expectancy of less than 2 years.

Design outcomes

Primary

MeasureTime frame
Pulmonary Function Tests;

Countries

China

Contacts

Public ContactPixin Ran

The First Affiliated Hospital, Guangzhou Medical University

pxran@gzhmu.edu.cn+86 13922765811

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026