Tuberculosis
Conditions
Interventions
Case series:Isoniazid
Sponsors
Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing, China
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Adults aged 18 to 65 years with a clinical diagnosis of tuberculous meningitis who can oral doses of isoniazid and the isoniazid was included in the treatment plan were eligible to enter the trial.
Exclusion criteria
Exclusion criteria: Patients were not eligible to enter the trial if they were obstructive hydrocephalus or serious tuberculous meningitis patients, or if the consent of either the patient or the patients relatives was not obtained. Other exclusion criteria were pregnancy and breastfeeding lactation, a known contraindication to isoniazid, HIV/ARDS, serious basic diseases, severe cardiovascular and cerebrovascular diseases, other disease of central nervous system. Or if the enrolling physician believed that the subjects have any particular disease not be fit for the research.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Plasma drug concentration;cerebrospinal fluid drug concentration;NAT2 genotype; | — |
Countries
China
Contacts
Public ContactHuang Hairong
Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing, China
Outcome results
None listed