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Clinical study of early pulmonary rehabilitation in improving the critcal patients with ventilator-induced diaphragmatic dysfunction

Clinical study of early pulmonary rehabilitation in improving the critcal patients with ventilator-induced diaphragmatic dysfunction

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR-OOC-17010955
Enrollment
Unknown
Registered
2017-03-23
Start date
2017-04-20
Completion date
Unknown
Last updated
2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ventilator-induced diaphragmatic dysfunction

Interventions

control group:ordinary multiple rehabilitation
treatment group:ordinary multiple rehabilitation +early pulmonary rehabilitation

Sponsors

Shenzhen Second People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: The patients (older than 18 years old) with invasive ventilation greater than 48h in diaphragmatic dysfunction. And meet the following screening conditions before weaning: 1. Induced respiratory failure of primary disease has been basically restored, and no new disease; 2. No serious arrhythmia, shock, severe infection and related complications, no motor neuron disease, chest and abdomen breathing movement coordination and no sternocleidomastoid muscle over-movement; 3. conscious or simple mental state examination scale(MMSE) score> 10 points; 4. Hb=90g/L; 5. No application of hyperensob or little dose of vasoactive drugs.Dopamine or norepinephrine <5 ~ 10ug / kg. Min); 6. No continuous application of depressant; 7. Have spontaneous breathing ability, cough reflex exist; 8. Oxygenation index: PaO2 / FiO2 = 200, PEEP = 5cmH2O, PaO2=60mmHg, and FiO2 = 40%, PH = 7.25; 9. No application of neuromuscular blocking agents; 10. neuromuscular blocking agents signed.

Exclusion criteria

Exclusion criteria: Unilateral pulmonary ventilation 1. Pregnancy, end-stage cancer patients, minors; 2. Cardiac, kidney and other organ severe damaged not corrected; 3. Severe malnourished patients; 4. Severe acid-base imbalance, electrolyte imbalance without correction; 5. Severe coagulation dysfunction without correction; 6. Acute stroke, unstable spinal injury; 7. Acute impatient infarction, deep vein thrombosis in patients; 8. Informed consent rejected.

Design outcomes

Primary

MeasureTime frame
blood albumin;BNP;thickness of diaphragm;The left ventricular ejection fraction;pressure of diaphragmatic;—

Countries

China

Contacts

Public ContactXiong Lihong

Shenzhen Second People's Hospital

13717007725@126.com+86 13717007725

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026