Viral hepatitis
Conditions
Interventions
Observation group:A total of 114 couples, fathers, enticavir0.5mg, q.d., oral
Observation group:mothers, HBVac, mothers were negative for anti-HBs vaccinated with the HBVac (0, 1, 6, recombinant yeast 20, or 40 µg
Control group:A total of 116 couples, they does not do any treatment
Sponsors
Qinhuangdao Third Hospital
Eligibility
Sex/Gender
All
Age
20 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. couples who tested negative for serum hepatitis A, C, D, and E viruses, and HIV; 2. without any alcoholic liver disease, drug-induced liver injury, and autoimmune liver disease; 3. normal renal function; 4. Singed informed consent forms by all couples; 5. All fathers had a medical history record of 2 to 25 years; 6. Venous blood from the neonates washarvested.
Exclusion criteria
Exclusion criteria: The researchers think the subjects poor adherence; The subjects has a history of hepatocellular carcinoma (HCC) or has a hint of hepatocellular carcinoma (HCC), such as, images of suspicious nodules and or AFP > 50 ng/mL; it may affect patients'treatment compliance, evaluation, or to the research plan any other serious or activities physical and mental diseases exist; The man in addition to the hepatitis B virus merging other infected with the virus; Spouse has hepatitis B virus infection and other virus infection.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Liver function;HBV-M;HBVDNA;The side effects of drugs, and safety;Compliance checks;physical examination; | — |
Countries
China
Contacts
Public ContactLihua Cao
Qinhuangdao Third Hospital
Outcome results
None listed