Osteonecrosis of the femoral head, Rheumatological diseases
Conditions
Interventions
Low-medium dose of glucocorticoids Group:The average dose of glucocorticoids is less than 40 mg/d in the first 3 months
High dose of glucocorticoids Group:The average dose of glucocorticoids is not less than 40 mg/d in the first 3 months
Sponsors
Shanghai Sixth People's Hospital
Eligibility
Sex/Gender
All
Age
14 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Meets the diagnostic classification criteria of rheumatological diseases; 2. Aged 14 - 75 years old; 3. New cases who require sustained glucocorticoids therapy,or those who were available with the full detailed dosages of glucocorticoids and other concomitant medications history; 4. Expected peak daily dose of glucocorticoids is above 20 mg or stable medication with long term,and the expected medication longer than six months or the total dosages are above 1500 mg; 5. Cases to be informed consent and who signed the informed consent approved by the Ethic Committee.
Exclusion criteria
Exclusion criteria: 1. With history of hip fractured or traumatic brain surgery; 2. Cases have been ostoenecrosis of the femoral head before taking glucocorticoids or have been hip replacement surgery; 3. Liver or kidney function is severely impaired (either of index of AST /ALT/ Ccr / BUN is two times higher than the upper limit of normal persons,respectively ),or cases with systemic failure. 4. Combined with rheumatoid arthritis, ankylosing spondylitis or hip arthritis; 5. Suffering from any malignant tumors; 6. Cases Combined with mental disorders, dementia who can not be normal communication and answered questions; 7. Cases are physically disabled with impaired mobility,or no fixed address; 8. Cases have been long-term glucocorticoids therapy and the amount of usage/dosages are not clearly identified; 9. Unwilling or unable to fit data collection; 10. Be not suitable for MRI checking(claustrophobic, with cardiac pacemakers, metal IUDs, etc.); 11. Pregnant or Lactating women and others who do not fit.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Observe the difference between glucocorticoids doses and the incidence of femoral head necrosis; | — |
Secondary
| Measure | Time frame |
|---|---|
| Determinate whether or not there is a dose-response relationship between cocorticoid dosages and incidence of the ONFH;Identification and validation of the genetic susceptibility associated with cocorticoid-induced ONFH; | — |
Countries
China
Contacts
Public ContactChangqing Zhang
Shanghai Sixth People's Hospital
Outcome results
None listed