The use of ventilation modes
Conditions
Interventions
VCV:Volume control ventilation
lung protective ventilation group:lung protective ventilation
Sponsors
Beijing Anzhen Hospital Capital Medical University
Eligibility
Sex/Gender
All
Age
25 Years to 70 Years
Inclusion criteria
Inclusion criteria: Patients scheduled for surgery under general anesthesia were eligible if they either (1) had proven CAD and were scheduled for pneumonectomy or (2) had =2 risk factors for CAD and were scheduled for pneumonectomy Proof of CAD was predefined as a history of myocardial infarctionor coronary revascularization, or a >50% stenosis on coronary angiography, or myocardial ischemia induced by radionuclide or echocardiographic stress testing. The predefined risk factors for CAD were age =70 years, diabetes mellitus requiring treatment (oral antidiabetic medications or insulin), arterial hypertension, history of stroke, functional capacity<4metabolic equivalent task, absence of sinus rhythm, and abnormal ECG (signs of left ventricular hypertrophy, left bundle branch block,or abnormalities of the ST-segment or T-wave).
Exclusion criteria
Exclusion criteria: We excluded patients in case of the following: (1) current medication with sulfonylurea derivatives or theophylline unless stopped =2 days before surgery because these drugs reportedly inhibit anesthetic preconditioning; (2) current congestive heart failure; (3) current unstable angina pectoris; (4) preoperative hemodynamic instability, defined as the use of vasopressors; (5) hepatic disease, defined as alanine aminotransferase and/or aspartate aminotransferase values >100 U/L; (6) renal insufficiency, defined as creatinine clearance >30 mL/min; (7) emergent surgery; (8) severe chronic obstructive pulmonary disease, defined as forced expiratory volume in the first second of expiration<1 L; (9) prior enrollment in the study; (10) concurrent enrollment in another RCT; (11) pregnancy; or (12) absence of written informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| pH;PO2;PCO2;VT;Ppeak;Pplat;Pmean;Cdyn;Raw; | — |
Secondary
| Measure | Time frame |
|---|---|
| HR;CVP;MAP;PV;MACC;CO;SV;FLTc;FLT;CI;TSVR;interleukin(IL)-6;tumor necrosis factor-a;COR;Blood sugar;Lactic acid;MPO;MDA;C-reactive protein;Troponin T;CK-MB;NT-proBNP;miRNAs;ECG; | — |
Countries
China
Contacts
Public ContactJun Ma
Beijing Anzhen Hospital Capital Medical University
Outcome results
None listed