schizophrenia
Conditions
Interventions
NC:collect fasting blood and morning urine
SZ-BL:Score the Positive And Negative Syndrome Scale(PANNS) and Life Event Scale(LES)
collect fasting blood and morning urine
SZ-4w:Score the Positive And Negative Syndrome Scale(PANNS)
collect fasting blood and first morning urine
Sponsors
The Second Xiangya Hospital of Central South University
Eligibility
Sex/Gender
All
Age
15 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Inpatients who met a clinical diagnosis of DSM-V of schizophrenia; 2. Men or women aged 15 to 60 with no alcohol and substance dependence or history of other central nervous system diseases, and no serious physical illness or chronic medication history; 3. First-episode antipsychotic-naive (FEAN) or relapsed cases who haven't taken antipsychotic drugs within a month, FEAN patients repeatedly admitted can be enrolled again at relapse if the psychiatrist judges that there is no need to change the treatment algorithm,which is restricted to monotherapy (olanzapine/risperidone); 4. Patients who were given either of the following antipsychotic treatment (atypical antipsychotics group: clozapine, olanzapine, risperidone, aripiprazole; typical antipsychotic haloperidol). Clinical treatment dose were measured by the doctors according to the patients condition. The experimenters only record cases and drug-related information; 5. Patients can take trihexyphenidyl, alprazolam as symptomatic treatment when they have extrapyramidal adverse reactions, but can not take other antipsychotic drugs.
Exclusion criteria
Exclusion criteria: 1. Patients with diabetes and severe liver and kidney dysfunction; 2. Patients with congenital QT prolongation or arrhythmia syndrome; 3. Schizophrenia patients with consolidation of the following diseases, such as epilepsy, Alzheimer's, alcohol and drug abuse, serious clinical somatic and mental disorders 4. Pregnant or breast-feeding women, or women who plan to having a baby during the study period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Stress markers; | — |
Secondary
| Measure | Time frame |
|---|---|
| Life event scale;Positve and Negative scale; | — |
Countries
China
Contacts
Public ContactHualin Cai
Department of Pharmacy, the Second Xiangya Hospital, Central South University
Outcome results
None listed