relapsed/refractory acute lymphoblast leukemia
Conditions
Interventions
experimental group:Chimeric antigen receptor T cells followed by allogeneic hematopoietic stem cell transplantation
Sponsors
Department of Hematology, Xinqiao Hospital, Third Military Medical University
Eligibility
Sex/Gender
All
Age
No minimum to 55 Years
Inclusion criteria
Inclusion criteria: 1) Male or Female; Aged below 55 years; 2) Refractory/relapsed acute lymphoblast leukemia with CD19 expression and no other effectvie way to select; 3) The estimated survial is over three months; 4) ECOG performance status of <=2 at study entry; 5) The important organs are function, such as heart and brain; 6)Understand and voluntarily sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1) The uncontrol infetion, HBV and HCV are positive; 2) The patients received any cell immunotherapy in the past.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| One-year disease-free survival; | — |
Secondary
| Measure | Time frame |
|---|---|
| Overall Survival;The Rate of graft-versus-host disease;The rate of infection; | — |
Countries
China
Contacts
Public ContactZhang Cheng
Department of Hematology, Xinqiao Hospital, Third Military Medical University
Outcome results
None listed