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The effect of microparticles from the blood of sepsis patients on vascular leakage in rats.

The role of vascular endothelial cell derived microparticles in vascular leakage after sepsis in rats

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR-OOC-16008352
Enrollment
Unknown
Registered
2016-04-24
Start date
2016-05-01
Completion date
Unknown
Last updated
2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sepsis

Interventions

Nomal control group and Sepsis patients group:Collect venous blood 10ml.

Sponsors

State Key Laboratory of Trauma, Burns and Combined Injury, Department 2, Institute of Surgery Research, Third Military Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: General variables 1. Fever (>38.3 degree C) or Hypothermia (core temperature 90/min–1 or more than two sd above the normal value for age; 3. Altered mental status; 4. Significant edema or positive fluid balance (>20 mL/kg over 24 hr); 5. Hyperglycemia (plasma glucose >140 mg/dL or 7.7 mmol/L) in the absence of diabetes. Inflammatory variables: 1. Leukocytosis (WBC count >12,000 uL–1) or Leukopenia (WBC count <4000uL–1); 2. Plasma C-reactive protein more than two sd above the normal value.

Exclusion criteria

Exclusion criteria: 1. History of chronic cardiovascular disease; 2. Pregnant woman or during the Menstrual period; 3. Malignant tumor or other severe disease.

Design outcomes

Primary

MeasureTime frame
Vascular leakage of rats.;

Countries

China

Contacts

Public ContactLiu Liangming

Third Military Medical University

liangmingliu@yahoo.com+86 13018380616

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026