postoperative cognitive dysfunction (POCD)
Conditions
Interventions
N/P/A:hydrogen inhalation
Sponsors
General Hospital of Tianjin Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. patients older than 75 years; 2. ASA I-III grade; 3. The patients were to be operated in the department of orthopedics under the anesthesia of lumbar anesthesia or epidural anesthesia or nerve block; 4. operation time was more one hours; 5. Patients have fully understood the nature of the study, voluntarily participated in this trial and signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. There are now or once patients with central nervous system diseases; 2. once accepted department of neurosurgery surgery; 3. patients with active liver disease; 4. patients taking sedative drugs or antidepressants during the study period; 5. suffering form severe visual or hearing impairment or inability to understand mandarin; 6. the same neuropsychological scales have been exposed; 7. already had COPD before surgery; 8. poor compliance or fail to complete the test according to the research plan; 9. clinical trials of other drugs in the past 4 weeks; 10. for any reason,the researchers think there is any situation that is not suitable for the selected.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MMSE;SOD;IL-6; | — |
Countries
China
Contacts
Public ContactXie Keliang
General Hospital of Tianjin Medical University
Outcome results
None listed