Alzheimer's Disease
Conditions
Interventions
Sponsors
The First Affiliated Hospital of Xi'an JiaoTong University
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: Case group: 1. Male or female and 50 to 80 years of age; 2. Diagnosed of primary hypertension; 3. Subjects with normal cognition or mild cognitive impairment; 4. Voluntarily signed informed consent. Control group: 1. Male or female and 50 to 80 years of age; 2. Without history of hypertension; 3. Sex , age and education were matched with the case group; 4. Voluntarily signed informed consent.
Exclusion criteria
Exclusion criteria: Case group: 1. Secondary hypertension; 2. Intracranial and extracranial vascular stenosis patients; 3. Apparent cerebral infarction or cerebral hemorrhage patients; 4. Patients with systemic diseases or other neurological diseases which may affect the cognitive function; 5. Patients with severe cardiovascular disease, lung disease, diabetes and other systemic diseases; 6. Patients with nervous system diseases or systemic diseases which may affect the autonomic nerve function; 7. Can't cooperate with cognitive function assessment; 8. Magnetic resonance imaging contraindication. Control group: 1. history of hypertension; 2. Intracranial and extracranial vascular stenosis patients; 3. Apparent cerebral infarction or cerebral hemorrhage patients; 4. Patients with systemic diseases or other neurological diseases which may affect the cognitive function; 5. Patients with severe cardiovascular disease, lung disease, diabetes and other systemic diseases; 6. Patients with nervous system diseases or systemic diseases which may affect the autonomic nerve function; 7. Can't cooperate with cognitive function assessment; 8. Magnetic resonance imaging contraindication.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| blood pressure variability;cognitive function;the level of plasma amyloid beta peptide and the related transport protein (sLRP - 1, sRAGE);vascular endothelial function :the level of NO, endothelin - 1, ROS;the degree of cerebral white matter demyelination and brain atrophy; | — |
Countries
China
Contacts
Public ContactQiumin Qu
The First Affiliated Hospital of Xi'an JiaoTong University
Outcome results
None listed