Apnoea of Newborn
Conditions
Interventions
ONE: A loading dose of 20 mg/kg of caffeine citrate was administered intravenously over 30 min within 24 hours of birth
then patients were maintained on a dose of 5 mg/kg/day over 10 min. The maintenance dose should be adjusted to 10 mg/kg/day if apnoea occured. When necessary,adjust the dose based 
Sponsors
The Third Affiliated Hospital of Guangzhou Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. The preterm infants younger than 37 weeks gestational age who received caffeine for the prevention of apnoea within 24 hours of birth; 2. at least one caffeine concentration; 3. agreed to sign informed consent.
Exclusion criteria
Exclusion criteria: Any congenital chromosomal abnormality, infection (sepsis con-firmed by blood culture), or neurologic condition were grounds for exclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| caffeine serum concentration; | — |
Secondary
| Measure | Time frame |
|---|---|
| Occurrence of (recurrent) apnoea;Acute drug side effects; | — |
Countries
China
Contacts
Public ContactSitu Bing
Outcome results
None listed