Nonalcoholic fatty liver disease
Conditions
Interventions
NA:NA
Sponsors
Shanghai Xinhua Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged from 18-65 years 2. Patients who had got pathological biopsy confirming NAFLD results within 6 months before enrolment 3. NAFLD biopsy sample could be collected for rereading 4. Willing to follow protocol requirement to identify if patients have MS according to IDF definition 5. Able and willing to give informed consent
Exclusion criteria
Exclusion criteria: 1. Chronic viral hepatitis, alcoholic liver disease (ALD), autoimmune liver disease, toxic liver damages and drug-induced liver injury; 2. End-stage liver disease such as cirrhosis and hepatocellular carcinoma (HCC); 3. Hepatolenticular degeneration (Wilson's disease) and other metabolic, genetic liver disease; 4. Pregnancy or breast feeding; 5. Unable to participate in the study due to any reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentage of NASH/ fibrosis in NAFLD patients confirmed by liver biopsy with or without MS; | — |
Secondary
| Measure | Time frame |
|---|---|
| Percentage of NAFL in NAFLD patients confirmed by liver biopsy with or without MS;Percentage of NAFL and NASH/ fibrosis in NAFLD patients confirmed by liver biopsy in different severity levels diagnosed by transient elastography;Percentage of NAFL and NASH/ fibrosis in NAFLD patients confirmed by liver biopsy in different severity levels diagnosed by ultrasonography (mild, moderate and severe);Percentage of NAFL and NASH/ fibrosis in NAFLD confirmed by liver biopsy patients with or without aminotransferase elevation;Percentage of NAFL and NASH/ fibrosis in NAFLD confirmed by liver biopsy patients with different CVD risk (low, intermediate and high). CVD risk will be estimated using the Framingham general CVD risk score (2008) algorithm;Percentage of different kind of symptoms in different pathological stage of NAFLD;CK-18 level in different pathological stage of NAFLD;Clinical characteristics of patients being biopsied; | — |
Countries
China
Contacts
Public ContactShujian Guo
Outcome results
None listed