Connective tissue disease associated pulmonary interstitial disease, pulmonary hypertension
Conditions
Interventions
study group:none
Sponsors
The First Affiliated Hospital of The Fourth Military Medical University. Xijing Hospital
Eligibility
Sex/Gender
All
Age
14 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. aged 14 to 65 years; weight more than 40kg; 2. diffuse connective tissue disease: rheumatoid arthritis (RA) in line with 1987 The American College of Rheumatology (ACR) classification standard; polymyositis / dermatomyositis (PM / (DM) in accordance with the 1982 Maddin diagnostic criteria; primary dry syndrome (pSS) Consistent with the 2002 European Study Group criteria; systemic lupus erythematosus (SLE) was in accordance with 1997; ACR revised SLE diagnostic criteria; systemic sclerosis (SSc) in accordance with 1980, ACR classification criteria; mixed connective tissue disease (MCTD) in accordance with the 1991 Kahn Diagnostic criteria. 3 classification criteria for the diagnosis of interstitial lung disease: HRCT Diffuse or focal pulmonary parenchymal density is increased, but the texture is clearly visible. Shadow: the performance of the honeycomb like lung, is the characteristic of pulmonary interstitial fibrosis, to two. Under the field of the lung with common; grid shadow: performance for the two lung field with pleural vertical. The thin wire like shadow, which is caused by the hyperplasia of the fibrous tissue in the small leaf spacing. Lung parenchyma density increased, the gas cavity disappeared. 4. diagnostic criteria for pulmonary hypertension: sea level resting state, right cardiac catheterization Measurement of pulmonary arterial pressure is greater than or equal to 25mmHg; the estimation of pulmonary artery systolic cardiac ultrasound TRV. The pressure is greater than or equal to 50mmHg; 5. Ptions had signed a Book of informed consent.
Exclusion criteria
Exclusion criteria: Does not conform to the standards of the entry group
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 6 minute walk test;Cardiac ultrasound;chest CT;Brain atrial natriuretic peptide;Right cardiac catheterization;blood gas analysis;pulmonary function; | — |
Secondary
| Measure | Time frame |
|---|---|
| C- reactive protein;ESR; | — |
Contacts
Public ContactPing Zhu
Outcome results
None listed